A systematic review on the role of beta adrenergic antagonists in diabetic foot ulcer

Vishnu Shivam; Vengojayaprassad S

Authors

Vishnu Shivam Final year MBBS student, Coimbatore Medical College and Hospital.
Dr. Vengojayaprassad S HOD, Department of Diabetology, Coimbatore Medical College and Hospital, Coimbatore..

Keywords:

Diabetic foot ulcer, Diabetic foot complications, Diabetic ulcer healing, Beta adrenergic antagonists, Beta blockers

Abstract

Diabetic foot ulcers are a constant threat to diabetic patients and can lead to amputations and even death. Beta antagonists have found to improve ulcer healing by inhibiting catecholamine effects such as keratin migration and wound epithelialization. The aim of this study is to review the available research articles on the usage of beta adrenergic antagonists in ulcer healing. A systematic search on PubMed database was carried out to review articles investigating the role of beta adrenergic antagonists on diabetic ulcer healing. Out of 133 records identified through electronic database search, finally 9 studies were included in the systematic review. The findings revealed that beta adrenergic antagonists such as timolol and propranalol as a topical cream accelerate ulcer healing process by enhancing anti-inflammatory and pro-angiogenic mechanisms.

References

Chang X, Li S, Xue XD, Chang F. Propranolol regulates ERK1/2 signaling pathway and promotes chronic wound healing in diabetic rats. Eur Rev Med Pharmacol Sci. 2019;23(10):4498-4506. doi:10.26355/eurrev_201905_17962

Yang HY, Fierro F, So M, et al. Combination product of dermal matrix, human mesenchymal stem cells, and timolol promotes diabetic wound healing in mice. Stem Cells Transl Med. 2020;9(11):1353-1364. doi:10.1002/sctm.19-0380

Zheng Z, Liu Y, Yang Y, Tang J, Cheng B. Topical 1% propranolol cream promotes cutaneous wound healing in spontaneously diabetic mice. Wound Repair Regen. 2017;25(3):389-397. doi:10.1111/wrr.12546

Gulcan E, Kuçuk A, Çayci K, et al. Topical effects of nebivolol on wounds in diabetic rats. Eur J Pharm Sci. 2012;47(2):451-455. doi:10.1016/j.ejps.2012.06.017

Romana-Souza B, Nascimento AP, Monte-Alto-Costa A. Propranolol improves cutaneous wound healing in streptozotocin-induced diabetic rats. Eur J Pharmacol. 2009;611(1-3):77-84. doi:10.1016/j.ejphar.2009.03.053

Fox JD, Baquerizo-Nole KL, Macquhae F, et al. Statins may be associated with six-week diabetic foot ulcer healing. Wound Repair Regen. 2016;24(2):454-457. doi:10.1111/wrr.12400

Thomas B, Kurien JS, Jose T, Ulahannan SE, Varghese SA. Topical timolol promotes healing of chronic leg ulcer. J Vasc Surg Venous Lymphat Disord. 2017;5(6):844-850. doi:10.1016/j.jvsv.2017.04.019