Canagliflozin induced euglycemic ketoacidosis in a 60-year-old diabetic male - A case report

Authors

  • Dr. V Ramya Mirunalini Resident, Department of Pharmacology, Coimbatore Medical College, Coimbatore, India.
  • Dr. Madhan L Professor & Head of the Department, Department of Pharmacology, Coimbatore Medical College, Coimbatore, India.
  • Dr. Hema P Assistant Professor, Department of Pharmacology, Coimbatore Medical College, Coimbatore, India.

Keywords:

Diabetes Mellitus, SGLT-2 inhibitors, Canagliflozin, Adverse Event, Hypotension, Euglycemic ketoacidosis

Abstract

Herein the authors present a case of adverse event of canagliflozin in a 60-year-old male with Type II Diabetes Mellitus. On Evaluation patient diagnosed to have euglycemic ketoacidosis. After stopping the drug canagliflozin and treated with IV fluids, his blood ketone levels came down. SGLT2 inhibitors are approved for use in T2DM and are not recommended in T1DM. Before starting on SGLT 2 Inhibitors its Extremely Important to evaluate the risk of Drug Induced Ketoacidosis.

References

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Fukuda M, Nabeta M, Muta T, Fukami K, Takasu O. Euglycemic diabetic ketoacidosis caused by canagliflozin: a case report. Int J Emerg Med. 2020 Jan 22;13(1):2.

Clement M, Senior P. Euglycemic diabetic ketoacidosis with canagliflozin: Not-so-sweet but avoidable complication of sodium-glucose cotransporter-2 inhibitor use. Can Fam Physician Med Fam Can. 2016 Sep;62(9):725–8.

Sampani E, Sarafidis P, Papagianni A. Euglycaemic diabetic ketoacidosis as a complication of SGLT-2 inhibitors: epidemiology, pathophysiology, and treatment. Expert Opin Drug Saf. 2020 Jun;19(6):673–82.

Adachi J, Inaba Y, Maki C. Euglycemic Diabetic Ketoacidosis with Persistent Diuresis Treated with Canagliflozin. Intern Med. 2017;56(2):187–90.

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Published

2023-02-01

How to Cite

V, R. M., L, M., & P, H. (2023). Canagliflozin induced euglycemic ketoacidosis in a 60-year-old diabetic male - A case report. The Journal of Medicine and Science, 2(01), 28–30. Retrieved from https://tjms.in/index.php/tjms/article/view/24

Issue

Vol. 2 No. 01 (2023): February 2023

Section

Case reports

License

Copyright (c) 2023 Dr. V Ramya Mirunalini, Dr. Madhan L, Dr. Hema P

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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