Therapeutic intervention of taste receptor expression in diabetes: A Systematic Review


  • Vishnu Shivam Final year MBBS, Department of General Medicine, Coimbatore Medical College and Hospital, Coimbatore, Tamil Nadu India.
  • Dr. Vengojayaprassad Senthipathi Professor & HOD, Department of Diabetology, Coimbatore Medical College and Hospital, Coimbatore, Tamil Nadu, India.


Diabetes Mellitus, Taste receptors, Taste agonists, Taste genes, Sweet taste gene, Salt taste gene


Background: Globally, diabetes is one of the leading causes of mortality, imposing a heavy global burden on public health as well as socioeconomic development. Genetic variation in taste receptor genes such as Sweet Taste Receptor type 1 & 2 (TAS1Rs & TAS2Rs), Transient Receptor Potential cation channel subfamily Melastatin member 5 (TRPM5), Nucleobindin 2 (NUCB2) and various other genes may play a causal role in the pathophysiology of obesity and diabetes. The aim of this study is to identify potential drugs targeting taste receptor expression in the treatment of diabetes. Materials and Methods: A systematic search of PubMed database was carried out to identify studies investigating Taste Receptors AND Diabetes Mellitus. Further, manual searching was conducted to identify relevant studies. Articles which assess therapeutic intervention of taste receptor expression in diabetic models were included. Results: The results showed various potential drugs targeting the expression of taste receptors at genetic level. This provides an effective way to prevent diabetes in a cost-effective way by supplementing compounds in commonly used food products. Conclusion: Our study revealed that therapeutic reversal of dysregulated taste receptor expression in diabetes may have the potential target in the treatment of diabetes. Furthermore, use of natural products and food supplements to regulate the taste receptor expression might be a cost-effective therapeutic and nutritive method in the battle against diabetes globally.


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How to Cite

Shivam, V., & Senathipathi, V. (2023). Therapeutic intervention of taste receptor expression in diabetes: A Systematic Review. The Journal of Medicine and Science, 2(01), 31–35. Retrieved from



Review article