SGLT 2 inhibitor dapagliflozin induced perineal soft tissue infection – A case report

Abstract

Herein the author presents a case report of perineal soft tissue infection after starting dapagliflozin in a 55 year old female with type II Diabetes Mellitus. Patient had redness, warmth, tenderness and induration over perineum. After stopping Dapagliflozin and treating her with insulin and IV antibiotics, patient improved clinically. Increased urinary excretion of glucose increases the risk of perineal soft tissue infection in patients with risk factors like obesity, poor perineal hygiene, hypertension, heart failure, very high blood glucose levels and those on immunosuppression. Maintaining perineal hygiene reduces the incidence of perineal soft tissue infection among patients who are on SGLT 2 inhibitor therapy.