Study of serum c-peptide level in newly detected diabetic patients in age group 30-40 years in tertiary care hospital - a cross sectional study


  • Dr. Bharathiraja G Assistant professor, Department of General Medicine, Coimbatore Medical College, Coimbatore, Tami Nadu, India.
  • Dr. Renugadevi S Senior resident, Department of General Medicine, Coimbatore Medical College & Hospital, Coimbatore, Tami Nadu, India.


Body Mass Index, diabetes, serum C-peptide, newly detected diabetes mellitus, treatment of diabetes mellitus, fasting blood sugar, postprandial blood sugar


Background: Serum C-peptide is the standard marker of endogenous insulin production and pancreatic β cell function. The present study was conducted with the aim to study serum C-peptide level in newly detected diabetes of age group 30-40 years in Tertiary care hospital in Tamilnadu.

Materials and methods:

It was a hospital based, cross sectional study. 100 newly detected diabetes mellitus patients of age group between 30-40 years were screened for fasting serum C-peptide levels and the relation between fasting serum C-peptide levels and age, gender, symptoms, family history of diabetes mellitus, Body Mass Index (BMI), central obesity and total cholesterol.

Results: The study results showed that, among 61 males, 8 (13%) had serum c-peptide level less than 0.5 and among females, 4(10.3%) had low serum    C-peptide. 88 (88%) of the study population had a fasting serum c-peptide value between 0.5-2 mg/dl and 12 (12%) had fasting serum C-peptide value less than 0.5.  68 (68%) of the study populations had cholesterol in range of ≤200 and 32 (32%) had cholesterol value from ≥200.

Conclusion: This study suggests measurement of serum c-peptide levels in newly detected diabetic subjects especially of younger age group is of value. However, there was no significant association between the fasting serum C- peptide level and age, gender, symptoms, family history of diabetes mellitus, BMI, central obesity and total cholesterol.


American Diabetes Association: Standards of medical care in diabetes. Diabetes Care 34:S11, 2011

WHO - International Health Federation. The Diabetes Action Now. Geneva: WHO; 2004.

World Health Report November 2010

Sarah Wild, Gojka Roglic, Anders Greus, Richard Sierce, Hilary King. Global prevalence of diabetes. Diabetes Care 2004;27:1047-53.

Das AK, Rai M. A world without diabetes and its complications: A preventive program. In: Type 2 Diabetes and its complications: A preventive program, Jayaram BM, ed. Bangalore: Micro Labs Limited; 2008. p. 1.

Alvin C Powers. Diabetic mellitus. 17th ed. Chapter 338. In: Harrison’s Principles of Internal Medicine, Braunwald, Fauci, Kasper, Hauser, Longo, Jameson. Loscalzo: McGraw-Hill Companies; 2008. p. 2275.

Pradeepa R, Deepa R, Mohan V. Epidemiology of diabetes in India - Current perspective and future projections. J Indian Med Assoc. 2002;100:144-8.

Diagnosis and classification of Diabetes mellitus. Diabetes Care 2009 Jan; 32(1):S62-S67.

King H. Global burden of diabetes 1995 to 2025. Prevalence, numerical estimates and projection. Diabetes Care 1998;21(9):1414-31.

Li Y, Li Y, Meng L, Zheng L. Association between serum C-peptide as a risk factor for cardiovascular disease and high-density lipoprotein cholesterol levels in nondiabetic individuals. PloS one. 2015; 10(1):e112281.

Chowta M, Adhikari P, Chowta N, Shenoy A, D’Souza S. Serum C peptide level and renal function in diabetes mellitus. Indian journal of nephrology. 2010; 20(1):25.

Standl E. Importance of _ cell management in type 2 diabetes. Int J Clin Pract Suppl 2007 June; (153): 10-19.

Jones A, Hattersley A. The clinical utility of C‐peptide measurement in the care of patients with diabetes. Diabetic Medicine. 2013; 30(7):803-17.

Lipsitt DR, Dimsdale J, Solomon D. Factitious disorder and munchausen syndrome. UpToDate com. 2007.

Ferranini E, Cobelli C. The kinetics of insulin in man. Role of the liver. Diabetes Metab Rev 1987; 3:365-97.

Zimmet P, Turner R, McCarthy D, Rowley M, Mackay I. Crucial points at diagnosis. Diabetes Care 1999;22:B59-B64.

Gupta S K et al. Diabetes prevalence and its risk factors in rural area of Tamil nadu. PIMS. 2010; 35(3): 396-369.

Prerna, Jadeja J.M and Naik Shobha S. Prevalence of Diabetes Mellitus type-2 in the general population of Ahmedabad city. International Journal of Basic and Applied Physiology. 2013; 2(1): 197-202.

American Diabetes Association. Clinical Practice Recommendations 2007. Diabetes Care 2007;30:S4.

Goutham V V N, Chaitanya M V K and Dasu K. Study of serum C-Peptide levels in 50 newly detected Diabetes subjects of age 30-40 years in Nellore. International Journal of Scientific and Technology Research. 2010; 2(10): 196-200.

Bharathiraja et al




How to Cite

G, B., & S, R. (2023). Study of serum c-peptide level in newly detected diabetic patients in age group 30-40 years in tertiary care hospital - a cross sectional study. The Journal of Medicine and Science, 2(01), 11–22. Retrieved from



Research article